id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320845-imxby1b1	Morley, G. L.	Sensitive detection of SARS-CoV-2-specific-antibodies in dried blood spot samples	2020-07-02		.txt	text/plain	1711	106	52	title: Sensitive detection of SARS-CoV-2-specific-antibodies in dried blood spot samples Objective: To validate the use of dried blood spot sampling for the detection of SARS-CoV-2-specific antibodies. Results: Specific anti-SARS-Cov-2 spike glycoprotein antibodies were detectable in both serum and DBS eluate and there was a significant correlation between the antibody levels detected in matched samples (r = 0.96, p<0.0001). Using serum as the gold standard in the assay, matched DBS samples achieved a Cohens kappa coefficient of 0.975 (near-perfect agreement), a sensitivity of 98.1% and specificity of 100%, for detecting anti-spike glycoprotein antibodies. . https://doi.org/10.1101/2020.07.01.20144295 doi: medRxiv preprint against matched serum in a highly sensitive and specific SARS-CoV-2 Enzyme Linked Immunosorbent Assay (ELISA). To detect antibodies to SARS-CoV-2-anti-spike (S) glycoprotein, matched serum and DBS titration curves were generated. We show that DBS samples can be used for the detection of SARS-CoV-2-specific antibodies with high levels of sensitivity and specificity and compared well with matched serum samples.	./cache/cord-320845-imxby1b1.txt	./txt/cord-320845-imxby1b1.txt