id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320729-imyfo83x	Spiga, Ottavia	Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein	2003-10-10		.txt	text/plain	2919	122	50	The S1 and S2 subunits of the spike glycoprotein of the coronavirus which is responsible for the severe acute respiratory syndrome (SARS) have been modelled, even though the corresponding amino acid sequences were not suitable for tertiary structure predictions with conventional homology and/or threading procedures. After sequence alignment of SARS S protein (SwissProt Accession Number P59594) with the corresponding ones from human and canine coronaviruses, model building of S1 and S2 subunits was obtained by using the latter two pdb files and shuffled PsiPred runs [13] , with subsequent manual optimisation to enhance the overlapping between the predicted and observed secondary structure elements. As a final remark, it should be underlined that the consistent series of structural features, exhibited by the proposed models for the S1 and S2 subunits of the SARS_CoV spike protein, supports their reliability as a possible rational starting point for anti-viral drug design.	./cache/cord-320729-imyfo83x.txt	./txt/cord-320729-imyfo83x.txt