id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320455-doup2bqq	Werion, Alexis	SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule	2020-08-10		.txt	text/plain	2871	182	44	Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed in the proximal tubule cells. At the structural level, kidneys from patients with COVID-19 showed prominent tubular injury, including in the initial part of the proximal tubule, with brush border loss, acute tubular necrosis, intraluminal debris, and a marked decrease in the expression of megalin in the brush border. Thus, our data establish that SARS-CoV-2 causes specific manifestations of proximal tubule dysfunction and provide novel insights into COVID-19 severity and outcome. The angiotensin converting enzyme 2 (ACE2), the receptor mediating the entry of SARS-CoV-2 in human cells, is expressed in the lung, heart, intestine and kidney, providing a rationale for the systemic manifestations of the disease [4] [5] [6] [7] . Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection	./cache/cord-320455-doup2bqq.txt	./txt/cord-320455-doup2bqq.txt