id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320401-itltvh3f	Clementi, Nicola	NARINGENIN IS A POWERFUL INHIBITOR OF SARS-CoV-2 INFECTION IN VITRO	2020-10-20		.txt	text/plain	1495	85	51	In the present insight, we highlight novel experimental evidence that the flavanone Naringenin, targeting the endo-lysosomal Two-Pore Channels (TPCs), could be added to the list of potential weapons against SARS-CoV-2 infection and COVID-19 disease. Noteworthy, our recent evidence has shown that the activity of human TPC channels can be inhibited by the natural flavonoid compound Naringenin (Nar) [4] , one of the main flavonoids present in the human diet. Images showed that Nar treatment did not cause toxicity on uninfected cells at any of the tested concentrations and DMSO (vehicle) did not significantly affect SARS-CoV-2 replication (Fig.1D-E) . Of note, results indicated a strong decrease of CPE (>90%) at 48hpi when Vero E6 cells were treated with 250 and 62.5 μM Nar (Fig.1E) . Differences between treated samples (n=4, n=3 at 72hpi) and controls (untreated infected cells, n=4, not shown) were significant Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection?	./cache/cord-320401-itltvh3f.txt	./txt/cord-320401-itltvh3f.txt