id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320333-audnwp8t	Chen, Qi-Lin	Localization of Cell Receptor-Related Genes of SARS-CoV-2 in the Kidney through Single-Cell Transcriptome Analysis	2020-05-19		.txt	text/plain	5260	293	58	BACKGROUND: The new coronavirus (SARS-CoV-2), which has been responsible for the recent coronavirus disease 2019 (COVID-19) pandemic, uses the cell receptor angiotensin converting enzyme-2 (ACE2) for entry and the serine protease TMPRSS2 for spike (S) protein priming. METHODS: The single-cell transcription datasets of the human cell landscape (HCL) and other relevant single-cell transcription databases were used to analyze the expression of ACE2, TMPRSS2, and SLC6A19 in various organs and tissues, but mainly in the kidney. The GSE121862 database is a combination of data from different experiments and institutions, and studies have suggested that single-nuclear transcriptome sequencing technology is more suitable in the kidney than other methods of gene expression analysis [25] . To compare cell receptor-related genes of SARS-CoV-2 in different tissues, high-quality single-cell transcriptome databases of the lung and small intestine were used for further analysis. For the first time from the single-cell level analysis, our results demonstrate that cell receptor-related genes of SARS-CoV-2 are differentially expressed in cell subgroups of different tissues.	./cache/cord-320333-audnwp8t.txt	./txt/cord-320333-audnwp8t.txt