id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320308-pzex799x	Erol, Adnan	Role of oxidized LDL-induced “trained macrophages” in the pathogenesis of COVID-19 and benefits of pioglitazone: A hypothesis	2020-05-12		.txt	text/plain	1916	129	43	CONCLUSIONS: When oxLDL-trained macrophages encounter SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in the lung, it causes unregulated cytokine secretion, leading to the alveolar damage. When oxLDL-trained macrophages encounter SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in the lung, it causes unregulated cytokine secretion, leading to the alveolar damage. CARD9 is critical adaptor protein and a central integrator in innate immune cell activation that triggers the inflammatory signaling pathway in response to viral infection. Consequently, while SARS-CoV-infection in oxLDL-trained macrophages cannot produce protective type I interferons, they readily potentiates existing low-grade inflammation through ASC-mediated caspase-1 activation [10, 11] . All COVID-19 patients who develop severe respiratory failure display hyper-inflammatory responses with features of either immune dysregulation or macrophage activation syndrome. The information provided here must match the contributors' statement in the manuscript.Importance of oxidized lipid-trained macrophages in the severity of COVID-19Adnan Erol Comment Role of the funding source Please disclose any funding sources and their role, if any, in the writing of the manuscript or the decision to submit it for publication.	./cache/cord-320308-pzex799x.txt	./txt/cord-320308-pzex799x.txt