id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319855-78xmxymu	BR, Bharath	In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19	2020-07-01		.txt	text/plain	4752	251	53	The three molecules streptomycin, ciprofloxacin, and GA had low interaction penalties and displayed better interactions with the ACE2 binding site on the RBD of SARS-CoV-2-S, as shown in Figure 8A -C, respectively. Further, in the RMSF plot for the RBD domain of the GA/SARS-CoV-2-S complex, shown in Figure 11C , the RMSF at loop region was 6.3Å with a high number of ligand contacts (green-coloured vertical bars), justifying the interactions seen in molecular docking. In the protein-ligand contact plot for the streptomycin/ SARS-CoV-2-S complex, shown in Figure 12A , residues Glu493 and Lys544 showed maximum interactions fractions, i.e. 0.20 facilitated by hydrogen bonds and water bridges. In the protein-ligand contact plot for the ciprofloxacin/ SARS-CoV-2-S complex shown in Figure 12B , residues Phe465, Tyr482, Tyr498, and Phe499 were seen to have the interactions fractions 0.75, 0.6, 0.35 and 0.39 respectively facilitated by hydrophobic, hydrogen bonds and water bridges.	./cache/cord-319855-78xmxymu.txt	./txt/cord-319855-78xmxymu.txt