id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319749-je0l22l5	Lippi, Alice	SARS‐CoV‐2: At the Crossroad Between Aging and Neurodegeneration	2020-04-24		.txt	text/plain	3090	190	43	Here, we posit that severe acute respiratory distress syndrome coronavirus 2 infection may, in the long-term, lead to accelerated aging phenotypes in survivors, not only in affected tissues but also in other organs, including the brain. 1, 2 As the causative agent of coronavirus disease 2019 (COVID19) , the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) is now responsible for the third coronavirus-associated pandemic in recent human history. SARS-CoV-2 proteins with human proteins from several aging-related pathways, like vesicle trafficking (Nsp6, Nsp7, Nsp10, Nsp13, Nsp15, Orf3a, E, and Orf8), lipid modifications (Spike), RNA processing and regulation (Nsp8, N), ubiquitin ligases (Orf10), and mitochondrial activity (Nsp4, Nsp8, and Orf9c). Moreover, Hsp40-NP interaction plays a role at the late stages of infection by inhibiting protein kinase R (PKR) activation, essential in the antiviral response of the host. 25 The infection with SARS-CoV induces the unfolded protein response (UPR) in the host cell.	./cache/cord-319749-je0l22l5.txt	./txt/cord-319749-je0l22l5.txt