id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318934-dxipu00r	Matsuyama, Shutoku	Enhancement of SARS-CoV Infection by Proteases	2006		.txt	text/plain	1861	109	56	Moreover, SARS-CoV entry from the cell surface mediated by proteases was a 100-fold more efficient infection than entry through endosomes. However, no S2 band was detected in SARS-CoV infected cells treated with proteases that failed to induce fusion. 3 stated that SARS-CoV is able to enter cells directly from their surface, if receptor-bound virus is treated with trypsin and other proteases that induce fusion. Treatment of VeroE6 cells with bafilomycin was shown to suppress SARS-CoV infection via the endosomal pathway to less than 1/100 (Fig. 2) . Pseudotype VSV bearing SARS-CoV S protein infection was also facilitated in bafilomycin-treated VeroE6 cells after treatment with proteases that induce fusion of SARS-CoV infected cells. These observations suggest that proteases that facilitate SARS-CoV entry from the cell surface support efficient SARS-CoV infection. Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry	./cache/cord-318934-dxipu00r.txt	./txt/cord-318934-dxipu00r.txt