id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318789-ylxh8vi2	Byrne, R. L.	Saliva offers a sensitive, specific and non-invasive alternative to upper respiratory swabs for SARS-CoV-2 diagnosis.	2020-07-11		.txt	text/plain	1875	133	62	Samples were classified as RT-qPCR positive if both the internal extraction and the SARS-CoV-2 probes were detected at <40Ct. Virus copies/ml were quantified using the manufacturer's positive control (1.67 Here we report for the first time the analytical sensitivity of saliva for the detection of SARS-CoV-2 compared to NT swab samples. In spiked saliva samples, SARS-CoV-2 can be detected with greater sensitivity in saliva compared to NT swabs by 100fold copies/ml, presumably due to the dilution factor of the amies transport medium. All saliva-positive, NT swab-negative samples in D2 (n=2) and D28 (n=1) reported low viral titre (<10 1 copies/ml) and are likely due to similar limitations outlined in the analytical sensitivity, a greater dilution factor of amies. This is in agreement with Wyllie et al., (2020) who reported that saliva had a greater sensitivity and was more likely to be constantly positive throughout the course of infection on a subset of COVID-19 hospitalised participants (n=29). Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 participants than nasopharyngeal swabs	./cache/cord-318789-ylxh8vi2.txt	./txt/cord-318789-ylxh8vi2.txt