id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318426-kv7aa0og	Kritsotakis, Evangelos I.	On the importance of population-based serological surveys of SARS-CoV-2 without overlooking their inherent uncertainties	2020-05-22		.txt	text/plain	1652	101	53	This brief note aims to explain the scope in conducting large-scale serological surveys of SARS-CoV-2 to define the landscape of population immunity, without overlooking the inherent uncertainty steaming from sampling design and diagnostic validity. The note completes with a succinct appendix of simple statistical methods for estimating prevalence from random population samples using imperfect diagnostic tests. They use serological tests to examine a large number of blood samples from people without a confirmed SARS-CoV-2 infection to detect signs that they were once infected with the virus. Available serological tests are not perfect but are acceptable for use in the context of surveying populations for SARS-CoV-2 antibodies, because survey estimates can be corrected for imperfect diagnostic performance. Large-scale seroprevalence surveys are an important tool in combating COVID-19 disease as they can provide much-needed estimates of the fraction of the population with antibodies against SARS-CoV-2. The quality of the antibody prevalence estimates depends on the sampling design and the diagnostic accuracy of serological tests.	./cache/cord-318426-kv7aa0og.txt	./txt/cord-318426-kv7aa0og.txt