id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318235-2e5er0x0	Yanai, Hidekatsu	Adiposity is the Crucial Enhancer of COVID-19	2020-08-01		.txt	text/plain	884	49	42	A very recent study showed that patients with overweight and obesity admitted in a medical ward for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related pneumonia, despite their younger age, required more frequently assisted ventilation and access to intensive care units (ICUs) or semi-ICU than normal-weight patients [1] . Increased DPP4 expression was observed in vascular endothelial cells, adipose tissue and liver in obese people [8] , which can also make it easy for SARS-CoV-2 to enter human tissues. It has been proposed that the increase of secretion of interleukin-6 and tumor necrosis factor-alpha by adipose tissue in obesity-induced insulin resistance, could underlie the associations of insulin resistance with endothelial dysfunction and coagulopathy [9] . Elevation of inflammatory cytokines, endothelial dysfunction and procoagulant state already exist in obese people even before SARS-CoV-2 infection. In conclusion, obese people have various factors including high likelihood of entry of SARS-CoV-2 into human vital tissues, elevated cytokines, endothelial dysfunction and procoagulant state, which may enhance the severity of COVID-19.	./cache/cord-318235-2e5er0x0.txt	./txt/cord-318235-2e5er0x0.txt