id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317379-ljdaj80d	Faure‐Bardon, V.	Anatomical and timely assessment of protein expression of angiotensin‐converting enzyme 2, SARS‐CoV‐2 specific receptor, in fetal and placental tissues: new insight for perinatal counseling	2020-08-15		.txt	text/plain	2190	157	54	Beyond theoretical assessment of risk and pathways for vertical transmission, the low incidence of perinatal infections might relate to a lower expression of ACE2 in the placenta and targeted organs. We aimed to evaluate protein expression of ACE2 both in placentas and in all fetal organs from pregnancies not infected with SARS-CoV2 at various gestational ages. Seven placentas were analyzed including 5 from the cases described above, 1 from a 7 weeks'-miscarriage, and 1 from a symptomatic infected pregnant woman with positive SARS-CoV2 RT-PCR delivered by cesarean section at 34 weeks'. These results broaden the insight on likelihood, pathways and morbidities of vertical transmission of SARS-CoV-2, providing a unique anatomical and timely validation of the protein distributions in fetal organs and placentas. The marked placental presence of the specific SARS-CoV2 receptor, ACE2, and its absence from the amnion suggests that ascending vertical transmission could mainly occur following rupture of the amniotic membranes.	./cache/cord-317379-ljdaj80d.txt	./txt/cord-317379-ljdaj80d.txt