id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317240-d7ioosi6	Shah, Niyati	Review: An insight into coronaviruses: Challenges, security and scope	2020-08-04		.txt	text/plain	2285	151	59	In principle, a molecule can act as an anti-viral drug if it inhibits some stage of the virus replication cycle, without being too toxic to the body cells. Out of these, the data of 8 patients could not be analyzed F I G U R E 2 A general mechanism of viral replication in host cells and functions of inhibitors at various stages during the process. A drug which is designed to be a fusion inhibitor will function at this stage by preventing the virus from binding with the receptor. This trial reported reduced mortality rates and also clinical improvements in 68% of the patients by the use of remdesivir. In cell culture, chloroquine shows activity against the SARS-CoV-2 virus, but the dosage requirements are usually high which may lead to serious toxicities if administered to humans. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza a (H1N1) 2009 virus infection	./cache/cord-317240-d7ioosi6.txt	./txt/cord-317240-d7ioosi6.txt