id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316979-uadlclsv	Pierri, Ciro Leonardo	SARS-CoV-2 spike protein: flexibility as a new target for fighting infection	2020-10-30		.txt	text/plain	1456	82	52	The recent study of Turoňová et al., is the first to combine cryoelectron tomography, subtomogram averaging, and molecular dynamics simulations for analyzing the structure of the SARS-CoV-2 spike protein in situ, 1 i.e. while the virus interacts with tissue cultured cells. Notably, in a recent analysis of conformational changes determining the post-fusion conformation observed for a similar coronavirus spike cryo-EM structure 5 and the related SARS-CoV-2 spike 3D comparative model 2 ( Fig. 1) , it was proposed that the loss of the N-terminal domain (residues 1-703, black cartoon) causes the reorientation of the 704-715 peptide, which was involved in maintaining the tight packing of the central helix (CH) and the heptad repeat 1 (HR1) domain, together with the N-terminal domain. Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies	./cache/cord-316979-uadlclsv.txt	./txt/cord-316979-uadlclsv.txt