id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316658-zwxtbena	Butler, S. E.	Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals	2020-08-06		.txt	text/plain	3487	225	45	SARS-CoV-2-specific IgA and IgG responses were often negatively correlated, particularly in mucosal samples, suggesting subject-intrinsic biases in isotype switching. In contrast to 168 observations in serum, nasal samples from subjects with severe disease showed little to no viral 169 neutralization, whereas subjects with elevated mucosal neutralization activity tended to have 170 experienced mild or moderate symptoms (Fig. 5b) . In contrast, the IgA-associated feature defined by nasal RBD-specific Abs binding to FcaR 226 ( Fig. 7C ) and its correlated function neutralization (Fig. 7D) were lowest in subjects with either mild or 227 severe disease, and elevated among those who recovered from moderate illness. Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding 580 domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein 581 induces strong mucosal immune responses and provides long-term protection against 582 SARS-CoV infection	./cache/cord-316658-zwxtbena.txt	./txt/cord-316658-zwxtbena.txt