id author title date pages extension mime words sentences flesch summary cache txt cord-316186-254z62e4 Kario, Kazuomi COVID‐19 and hypertension—evidence and practical management: Guidance from the HOPE Asia Network 2020-07-09 .txt text/plain 3315 197 43 1 Early clinical experience suggested that older age and the presence of a number of comorbidities, including hypertension, cardiovascular disease, diabetes mellitus and chronic respiratory disease increased the risk of death in patients with 3 In addition, the renin-angiotensin aldosterone (RAS) system (specifically the angiotensin-converting enzyme 2 [ACE2] protein) has been identified as playing an important role in facilitating entry of coronaviruses, including SARS-CoV-2, into target cells, especially in the lungs. Despite the theoretical possibility that use of RAS inhibitors increases the risk of infection with SARS-CoV-2 and the severity of COVID-19 illness, analyses including patients from the current pandemic indicate that this does not seem to be the case ( Table 2 ). Association of renin-angiotensin system inhibitors with severity or risk of death in patients with hypertension hospitalized for coronavirus disease 2019 (COVID-19) infection in Wuhan, China ./cache/cord-316186-254z62e4.txt ./txt/cord-316186-254z62e4.txt