id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316018-zrui9i5z	Bristow, Michael R.	Dynamic Regulation of SARS-CoV-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium	2020-06-24		.txt	text/plain	3527	172	43	SUMMARY Using serial analysis of myocardial gene expression employing endomyocardial biopsy starting material in a dilated cardiomyopathy cohort, we show that the SARS-CoV-2 cardiac myocyte receptor ACE2 is upregulated with remodeling and with reverse remodeling down-regulates into the normal range. Using serial analysis of myocardial gene expression employing endomyocardial biopsy starting material in a dilated cardiomyopathy cohort, we show that the SARS-CoV-2 cardiac myocyte receptor ACE2 is upregulated with remodeling and with reverse remodeling downregulates into the normal range. In explanted human heart preparations from patients with end stage reduced ejection fraction heart failure (HFrEF), ACE2 enzyme activity (22) as well as gene expression at the mRNA (20,23) and protein (20,22) levels are upregulated compared to organ donor controls. F/NDC baseline data for 10 integrins previously reported to bind to ACE2 (18,19), facilitate viral internalization (17) or be associated with LV remodeling (36) or cardiac myocyte injury protection (37) .	./cache/cord-316018-zrui9i5z.txt	./txt/cord-316018-zrui9i5z.txt