id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315652-hct9yh3n	Wehbe, Zena	Molecular Insights Into SARS COV-2 Interaction With Cardiovascular Disease: Role of RAAS and MAPK Signaling	2020-06-03		.txt	text/plain	6560	372	41	As such, a thorough understanding of the signaling pathways common to the pathogenesis of CVD and SARS-CoV-2 infection is necessary to identify crucial sites of crosstalk and direct future investigation of potential therapeutic interventions mitigating both COVID-19 complications in CVD patients as well as short-and long-term viral-induced cardiovascular impairment. The chronic nature and gradual development timeframe of these diseases might argue that the crosstalk among increased MAPK signaling cascades and SARS-CoV-2 pathogenesis leads to increased infection severity and complications in patients with established CVD rather than being involved in viraltriggered cardiovascular involvement. This raises the possibility for a beneficial effect of eplerenone or other aldosterone receptor antagonists in reducing risk of severe COVID-19 infection in CVD patients or to mitigate the cardiovascular burden of SARS-CoV-2 infection.	./cache/cord-315652-hct9yh3n.txt	./txt/cord-315652-hct9yh3n.txt