id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315289-4x229n8n	Foresta, C.	Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome	2020-09-16		.txt	text/plain	3417	166	43	Although it is assumed that older men have more comorbidities than women of similar age, a tentative hypothesis to explain these epidemiologic findings is the role of the angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 engages ACE2 in alveolar epithelial On the top of the figure, epidemiological data from the Italian Ministry of Health are reported, with respective gender distribution of cases and deaths. The lack of increased ACE2 pool in men due to low estrogens would favor the ACE pathway (red arrows) in the RAS axis, which further promotes tissue injury and disease severity in men, compared with women with the same viral load cells as the entry receptor and employs the serine protease TMPRSS2 for S protein priming [8, 9] . Altogether, available evidence points toward two not-mutually exclusive mechanisms in differential gender susceptibility to COVID-19 by sex hormonal regulation of the two main actors in SARS-CoV-2 infection: ACE2 and TMPRSS2.	./cache/cord-315289-4x229n8n.txt	./txt/cord-315289-4x229n8n.txt