id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314013-g091lv0s	Belladonna, Maria Laura	Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19	2020-06-19		.txt	text/plain	2388	119	35	Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients. If a cytokine storm occurs, the ensuing cytokine release syndrome (CRS) is typically associated with severe, rather than moderate, COVID-19, with an immunopathology being characterized by high serum levels of cytokines, CD4 + and CD8 + T (but not B) cell lymphopenia, diffused alveolar damage, pulmonary hypertension, pneumonia, and acute RDS (Pedersen and Ho, 2020) . COVID-19 is associated to a CRS referred as "cytokine storm" (A), whose reduction at lung level (the main target organ of SARS-CoV2 viral infection) may be achieved by TCZ therapy inhibiting IL-6 proinflammatory effect (B). TCZ treatment might restore a proper IDO1 activity, providing immunoactive Kyn as a ligand for AhR-dependent immune regulation, including the fostering of T-regulatory cell responses.	./cache/cord-314013-g091lv0s.txt	./txt/cord-314013-g091lv0s.txt