id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-313458-ka02rsla	Zhou, Yitian	Single-cell transcriptional profile of ACE2 in healthy and failing human hearts	2020-09-01		.txt	text/plain	1695	86	46	To explore the potential mechanisms contributing to this finding, we examined the expression of ACE2 in the different cells of the heart for heart samples from healthy individuals and heart failure patients and compared the results between these two groups. We found that the expression of ACE2 in cardiomyocytes was significantly increased compared to the other cells in the heart failure patients ( Figure 1L ). These results suggest that the cardiomyocytes of heart failure patients may be directly attacked by the virus and that this may contribute to the development of myocardial injury and severe conditions. We speculate that SARS-CoV-2 mainly attacks pericytes via ACE2, which leads to coronary microvascular disorder and myocardial injury in COVID-19 patients. This finding suggests that heart failure patients infected by the SARS-CoV-2 virus may suffer viral myocarditis and severe myocardial injury by direct attack on their cardiomyocytes.	./cache/cord-313458-ka02rsla.txt	./txt/cord-313458-ka02rsla.txt