id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-313349-ikjivfce	Finsterer, Josef	Causes of hypogeusia/hyposmia in SARS‐CoV2 infected patients	2020-04-20		.txt	text/plain	1132	85	49	It is well appreciated that SARS‐CoV2 does not exclusively affect the lungs.(1,2) Virus‐RNA can be detected in most of the body compartments, including the cerebrospinal fluid (CSF).(3) Neurological manifestations have been recently investigated in a retrospective study of 214 SARS‐CoV2‐infected patients.(1) This article is protected by copyright. A further argument against hypothesis one is that SARS-CoV2-associated meningitis is rare Accepted Article but smelling/taste abnormalities are frequent. In COVID-19 patients, ACE2-expressing cells of the taste buds and/or olfactory epithelium might be targeted by SARS-Cov2 via a cytopathic effect. 15 Besides the hypothesis of a cytopathic effect on neurosensory cells, the high incidence of smell and/or taste loss in COVID-19 patients might thus reflect the impact of SARS-Cov2 on the synthesis of neurotransmitters (notably serotonin and dopamine) by ACE2-expressing cells. In summary, the most likely cause for transient hypogeusia and hyposmia in SARS-CoV2-infected patients is a direct contact and interaction of the virus with gustatory receptors or olfactory receptor cells.	./cache/cord-313349-ikjivfce.txt	./txt/cord-313349-ikjivfce.txt