id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312991-ypgrw78s	Wang, Zhi-Gang	Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV	2005-09-12		.txt	text/plain	3744	224	64	In this study, we have identified 876 polymorphism sites in 145 complete or partial genomes of SARS-CoV available in the NCBI GenBank. According to 5 polymorphism sites, 63 SARS-CoV genomes were divided into early, middle and late phase genotype groups [19] . Key mutation loci are shown in Table 3 (identified by using nucleotide-nucleotide BLAST program at NEBI and Clustalw 1.83), and the phylogenetic tree of 174 loci ( Fig. 1) showed that, according to the polymorphism sites of C9404T, C9479T, G17564T, G19838A, A21721G, C22222T, G22517A, G23823T, T27243C and C27827T, the SARS-CoV genomes of the first epidemic can be divided into two genotypes, genotype C and T. among the genotypes and the groups The genetic characteristics of the genotypes were further analyzed based on the sequence polymorphism of the spike protein genes ( Table 4 ). SARS-CoV GD03T0013 was from the patient with ''mild clinical symptoms'', and its genome sequence was similar to that of the sub-genotype C1.	./cache/cord-312991-ypgrw78s.txt	./txt/cord-312991-ypgrw78s.txt