id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312884-anlp8lab	Iyer, Gayatri R.	Infectivity and Progression of COVID-19 Based on Selected Host Candidate Gene Variants	2020-09-04		.txt	text/plain	6268	317	44	Materials and Methods: Clinical exome data of 103 individuals was analyzed to identify sequence variants in five selected candidate genes: ACE2, TMPRSS2, CD209, IFITM3, and MUC5B to assess their prevalence and role to understand the COVID-19 infectivity and progression in our population. The aim of the present study was to identify variants in these five selected candidate genes from the clinical exome data available with us for more than 100 individuals and make an attempt to classify them as relevant to the present COVID-19 aetiopathology, especially for the Indian population. The selected candidate gene variants were assessed in our internal cohort of 103 individuals, who had earlier provided consent, to perform a pilot study on the susceptibility and disease severity of Indians for COVID-19. Since host genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection, in this study five candidate genes-ACE2, TMPRSS2, CD209, IFITM3, and MUC5B-were selected based on their relevance to the current pandemic.	./cache/cord-312884-anlp8lab.txt	./txt/cord-312884-anlp8lab.txt