id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312275-plqturzi	Nielsen, Sandra C.A.	Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2	2020-09-03		.txt	text/plain	2624	219	65	To directly test the 154 antigen specificity of these convergent clones, we expressed human IgG1 monoclonal antibodies 155 (mAbs 2A and 4A, Table S2 ) from two COVID-19 convergence groups in two patients 156 following paired immunoglobulin heavy and light chain sequencing of single B cells with the immunosorbent assay (ELISA) testing, both mAbs bound SARS-CoV-2 spike and S1 domain, 160 but not the RBD or nucleocapsid ( Figure 3C ). To evaluate whether such in silico IGH 185 sequence comparisons could predict the serological responses of patients, we tested the plasma 186 samples from COVID-19 patients in SARS-CoV RBD ELISAs and detected cross-reactivity in 187 five of the 13 patients ( Figure 3F) or RBD antigens will also stimulate B cells expressing these common antibody types in a 214 significant fraction of the human population.	./cache/cord-312275-plqturzi.txt	./txt/cord-312275-plqturzi.txt