id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311477-gm0vg53l	Doboszewska, Urszula	Targeting zinc metalloenzymes in COVID‐19	2020-07-15		.txt	text/plain	6194	327	49	We attempt to integrate data on the effects of agents targeting zinc fingers in viral metalloenzymes (zinc fingers targeting agents), which cause removal of zinc from the proteins, thus destabilizing the proteins and leading to increased intracellular concentration of zinc ions, and other agents which induce changes in intracellular levels of zinc (zinc ionophores), with data on consequences of altered level of intracellular zinc, with a focus on SARS-CoV-2 and related pathogens. Chloroquine, an old antimalarial drug (Blount, 1967) , was demonstrated to block virus infection at low micromolar concentration in Vero E6 cells infected with SARS-CoV-2 , thus suggesting the possible use of chloroquine in patients with COVID-19. With regard to COVID-19, a novel drug would target labile zinc fingers in SARS-CoV-2 proteins, thus destroying the proteins and producing an increase in intracellular concentration of zinc ions.	./cache/cord-311477-gm0vg53l.txt	./txt/cord-311477-gm0vg53l.txt