id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310928-g553afo9	Murch, Simon H	Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14	2020-08-07		.txt	text/plain	3724	224	46	In contrast to the SARS secreted glycoprotein (SGP), SARS-CoV-2 SGP are thus potential ligands for Sialic acid-binding Siglecs on host immune cells, known to regulate immune function. CD33 + MDSC populations release Arginase-1 to cause arginine depletion, inducing decreased T cell receptor (TCR)- chain expression and impaired adaptive immune responses 20, 21 . There is so far no clear consensus on their eventual phenotype but these new marrow derived cells are initially characterised as Early stage MDSC (eMDSC), which do not initially express lineage markers but do express CD33 and would thus be susceptible to SARS-CoV-2 SGP manipulation until the virus was cleared ( Figure 3 ). In due course, this might allow persons who fail to respond to immunisation to be pre-treated to block Siglec binding sites, allowing them to be exposed to small infecting doses of SARS-Cov-2 in clinically controlled circumstances and thus generate a broad immune response, including to the pathogenic glycan determinants	./cache/cord-310928-g553afo9.txt	./txt/cord-310928-g553afo9.txt