id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310879-b8tdug93	Beddingfield, Brandon J.	In the Age of CoVID: Genomic Changes Over the Lifespan Help Explain Severe SARS-CoV-2 Disease	2020-10-23		.txt	text/plain	615	47	62	Because additional receptor interactions have been implicated in host cell invasion by previous coronaviruses, other receptors have been investigated for their potential role in SARS-CoV-2 infection. Previous studies have also The potential entry gene BSG was found to be in higher abundance in cardiorenal tissues than in the lung, though it was well expressed in all tissues examined. This is in contrast to ACE2, which was found to be expressed at low levels in lung, but higher levels in cardiorenal tissues (kidney, heart and blood vessels) across the individuals examined. Taken together, this could explain the higher levels of viral replication in lung tissue for SARS-CoV-2, even if the receptor itself is not highly expressed. Males also had an increased expression of BSG, PPIA, PPIB in endothelial cells, and higher levels of ACE2 and TMPRSS2 in the coronary artery. Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD	./cache/cord-310879-b8tdug93.txt	./txt/cord-310879-b8tdug93.txt