id author title date pages extension mime words sentences flesch summary cache txt cord-310606-msmh7d8m Westerhuis, B. M. Severe COVID-19 patients display a back boost of seasonal coronavirus-specific antibodies 2020-10-12 .txt text/plain 4297 306 65 . https://doi.org/10.1101/2020.10.10.20210070 doi: medRxiv preprint All patients mounted a strong SARS-CoV-2 immune response shown by rising IgG titers against 174 SARS2-SECTO, SARS2-S1 and SARS2-SRBD which peaked around 4 weeks post onset of clinical 175 symptoms ( Figure 1A and Supplementary figure 1A for individual patients). Besides the SARS-CoV-2 IgG response, serum IgG reactivity towards various, but not 183 all seasonal CoV antigens, increased in longitudinally analyzed COVID-19 patients ( Figure 1A is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint However, cross-reactivity 282 between OC43-SECTO and SARS-CoV-2 S antigens showed significant weak negative 283 correlations (range R=-0.038 --0.088, range p=4,7x10 -6 -0.014) suggesting that OC43-S ECTO 284 specific clones are unlikely to cross-react with SARS-CoV-2 S in severe COVID-19 patients 285 ( Figure 3B ). ./cache/cord-310606-msmh7d8m.txt ./txt/cord-310606-msmh7d8m.txt