id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310605-r63sg73c	Dorward, D. A.	Tissue-specific tolerance in fatal Covid-19	2020-07-04		.txt	text/plain	4482	256	39	Here we report an aberrant immune response in fatal Covid-19, principally involving the lung and reticuloendothelial system, that is not clearly topologically associated with the virus, indicating tissue-specific tolerance of SARS-CoV-2. This supports prioritising pathogen tolerance as a therapeutic strategy in Covid-19, by better understanding non-injurious organ-specific viral tolerance mechanisms and targeting aberrant macrophage and plasma cell responses. As analysis of SARS-CoV-2 RNA confirmed presence in numerous organs, detailed histological analysis of multiple tissues was undertaken on every patient to determine the associated pathological consequences and inflammatory responses. The present study shows that fatal Covid-19 is associated with variable but widespread distribution of viral RNA and protein but with a discordant inflammatory response to local viral presence, both between and within tissues, demonstrating tissue-specific tolerance of SARS-CoV-2.	./cache/cord-310605-r63sg73c.txt	./txt/cord-310605-r63sg73c.txt