id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310091-x31g02xw	Zhang, Zhilan	Pan-cancer analysis reveals that ACE2 is positively associated with immunotherapy response and is a potential protective factor for cancer progression	2020-09-02		.txt	text/plain	2941	169	42	Using cancer genomics datasets from the Cancer Genome Atlas (TCGA) program, we performed computational analyses of associations between ACE2 expression and antitumor immunity, immunotherapy response, oncogenic pathways, tumor progression phenotypes, and clinical outcomes in 13 cancer cohorts. A recent study [9] showed that ACE2 expression was associated with increased tumor immune infiltration and was a positive prognostic factor in uterine corpus endometrial and renal papillary cell cancers. Despite these previous studies, a systemic investigation into the association between ACE2 expression and antitumor immunity, oncogenic pathways, tumor progression phenotypes, and clinical outcomes in pan-cancer remains lacking. We also explored associations between ACE2 expression and multiple tumor phenotypes, including cell proliferation, stemness, epithelial-mesenchymal transition (EMT), oncogenic signaling, and clinical outcomes in these cancer cohorts. We found that ACE2 expression levels inversely correlated with the activity of cell cycle, mismatch repair, TGF-β, Wnt, VEGF, and Notch signaling pathways in 10, 7, 9, 7, 5, and 7 individual cancer types, respectively (Spearman's correlation test, FDR < 0.05) ( Fig. 2A) .	./cache/cord-310091-x31g02xw.txt	./txt/cord-310091-x31g02xw.txt