id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310051-bl8l4bgo	Leitner, Thomas	Where did SARS-CoV-2 come from?	2020-07-06		.txt	text/plain	1185	78	55	Based on genomic CpG dinucleotide patterns in different coronaviruses from different hosts, it was suggested that SARS-CoV-2 might have evolved in a canid gastro-intestinal tract prior to transmission to humans. However, similar CpG patterns are now reported in coronaviruses from other hosts, including bats themselves and pangolins. While it is possible that a bat coronavirus jumped directly to a human, the closest known bat virus, RaTG13 found in a Rhinolophus affinis bat , shows 96% genomic similarity to SARS-CoV-2. Canine coronaviruses were not the only viruses with CpG patterns similar to those observed in SARS-CoV-2. Therefore, reduced genomic CpG content alone cannot predict the zoonotic origin of SARS-CoV-2, even though Xia (2020) (Pollock et al. Identification of the zoonotic origin of SARS-CoV-2 may be particularly challenging, as coronaviruses frequently recombine and are found in many different host species in the wild (Graham and Baric 2010) .	./cache/cord-310051-bl8l4bgo.txt	./txt/cord-310051-bl8l4bgo.txt