id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310008-hwpn7ti1	Lyons-Weiler, James	Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity	2020-04-09		.txt	text/plain	2090	122	45	Failure of SARS and MERS vaccines in animal trials involved pathogenesis consistent with an immunological priming that could involve autoimmunity in lung tissues due to previous exposure to the SARS and MERS spike protein. In this study, I present the likely human epitopic targets of biomimicry-induced autoimmunological components of morbidity and mortality caused by SARS-CoV-2 infection. This is achieved via bioinformatics analysis of the homology between highly immunogenic SARS-CoV-2 epitopes and human proteins to promote comprehension of the etiologies of pathogenesis of SARS-CoV-2 in COVID-19. A list of human peptides with high local homology was compiled and their roles in the pathogenesis of COVID-19 from SARS-CoV-2 infection noted. Remarkably, over 1/3 (11/27) of the immunogenic proteins in SARS-CoV-2 have potentially problematic homology to proteins that are key to the human adaptive immune system (emboldened in Table 1 ).	./cache/cord-310008-hwpn7ti1.txt	./txt/cord-310008-hwpn7ti1.txt