id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309915-isw1arrp	Perez-Jurado, L. A.	Immune defects and cardiovascular risk in X chromosome monosomy mosaicism mediated by loss of chromosome Y. A risk factor for SARS-CoV-2 vulnerability in elderly men?	2020-04-24		.txt	text/plain	3328	200	49	The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) has an estimated overall case fatality ratio of 1.38% in China, being 53% higher in males and increasing exponentially with age. Using comparative transcriptomic data, we have defined that XCM/LOY is associated with abnormal peripheral blood cell counts with decreased progenitor cells and multiple biomarkers of immune system dysfunction, pro-coagulation activity and increased cardiovascular risk. 8 Individuals with XCM have an increased risk for autoimmune disease, recurrent viral infections and earlier cardiovascular mortality, 9 which has been attributed to X-chromosome haploinsufficiency for multiple genes, and is associated with excessive production of proinflammatory cytokines (IL-6), decrease in anti-inflammatory cytokines (IL-10, TGF-β) and a lower CD4:CD8 ratio. 19.20071357 doi: medRxiv preprint Association analysis between LOY status and clinical data, including blood cell counts and biochemical parameters, was assessed using linear models adjusted by age.	./cache/cord-309915-isw1arrp.txt	./txt/cord-309915-isw1arrp.txt