id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309794-scqkyr5g	Sharif‐Askari, Fatemeh Saheb	Are patients with chronic rhinosinusitis with nasal polyps at a decreased risk of COVID‐19 infection?	2020-08-05		.txt	text/plain	1885	105	52	In fact, higher SARS-CoV-2 viral load was detected in nasal compared to throat swabs obtained from COVID-19 infected patients [4] , and that was attributed to the difference in ACE2 expression between both tissues. Interestingly, a significant reduction in the expression of ACE2 and TMPRSS2 was observed in the nasal polyps of CRSwNPs patients compared to healthy controls ( Figure 1A ). This data suggest that eosinophilic inflammation and the associated type 2 cytokines downregulate the expression of ACE2 in nasal tissue of CRS patients and thus may have a protective role against COVID-19 infection. In conclusion, as presented in Figure 2 , our data suggest that the type of inflammation underlying CRS, as well as corticosteroid treatment, may modulate ACE2 and TEMPRSS2 gene expression levels in the nasal polyps of CRSwNPs patients.	./cache/cord-309794-scqkyr5g.txt	./txt/cord-309794-scqkyr5g.txt