id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309554-ctc84tfy	Pang, Ronald TK	Serum Proteomic Fingerprints of Adult Patients with Severe Acute Respiratory Syndrome	2006-03-01		.txt	text/plain	5189	273	52	To identify proteomic features associated only with disease, we used 2 criteria: (a) the normalized peak intensities had to be significantly higher/lower in SARS patients than in non-SARS individuals; and (b) the normalized peak intensities had to correlate with 2 or more clinical/ biochemical variables, indicating their biological meaningfulness. These potential biomarkers were found to be significantly associated with SARS-CoV viral load (2 correlated with SARS-CoV RNA), acute-phase reaction [ differentiation of sars by two-way hierarchical clustering analysis of serum proteomic fingerprints We successfully identified potential biomarkers reflecting various physiologic or pathologic responses of the body to SARS infection, including acute-phase reaction (7, 17 ) , lung damage (18 -20 ) , impairment of liver function (21) (22) (23) , neutrophil activation (24 -26 ) , and viral load (5, 10, 27, 28 ) . Protein chip array profiling analysis in patients with severe acute respiratory syndrome identified serum amyloid a protein as a biomarker potentially useful in monitoring the extent of pneumonia	./cache/cord-309554-ctc84tfy.txt	./txt/cord-309554-ctc84tfy.txt