id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309206-kq77whdx	Yan, Victoria C.	Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment	2020-06-23		.txt	text/plain	2300	155	49	13 Seeing that the enzymes involved in McGuigan prodrug hydrolysis are hardly expressed in the lungs undermines its utility in the context of a primarily respiratory disease such as Covid-19. 4−6 For the fleeting duration of time that remdesivir is in the blood (prior to hydrolysis to GS-441524), the expression of bioactivating enzymes for McGuigan prodrugs suggests that the highest concentrations of NTP formation by remdesivirrather than GS-441524 would occur in cell types with high expression of CES1/ CTSA/HINT1. 26 At the time of publication, a study by Agostini and colleagues is the only report that has compared the antiviral activities of GS-441524 and remdesivir in primary human airway epithelial (HAE) cells, the most clinically relevant in vitro model of the lung, infected with either SARS-CoV or MERS-CoV. 1 Above all else, premature hydrolysis of the McGuigan prodrug, followed by dephosphorylation in serum such that GS-441524 is the predominant metabolite 4,5,29 compels studies investigating its utility in patients with Covid-19.	./cache/cord-309206-kq77whdx.txt	./txt/cord-309206-kq77whdx.txt