id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308507-hp6m6qrn	Gan, Yi-Ru	Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase	2005-10-19		.txt	text/plain	1570	98	62	The results demonstrate that, compared with other compounds reported so far, AVLQSGFR is the most active in inhibiting replication of the SARS coronavirus, and that no detectable toxicity is observed on Vero cells under the condition of experimental concentration. These authors had done studies of docking the octapeptide to SARS-CoV M pro based on the three-dimensional structure of SARS coronavirus main proteinase obtained by Anand et al. The binding results obtained through docking study [10] and structural bioinformatics [7] show that the octapeptide AVLQSGFR is bound to the SARS proteinase through six hydrogen bonds. The present study was initiated in an attempt to conduct an in-depth examination of the antiviral activity of the octapeptide AVLQSGFR against SARS-associated coronavirus by biochemical experimental approaches. We also detected the effect of the octapeptide AVLQSGFR on replication of SARS-associated coronavirus in Vero cells (Fig. 2) .	./cache/cord-308507-hp6m6qrn.txt	./txt/cord-308507-hp6m6qrn.txt