id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308499-xqmguqyi	Ahmed, Sakir	Reply to Rheumatologists’ perspective on coronavirus disease 19: is heparin the dark horse for COVID-19?	2020-05-09		.txt	text/plain	678	47	43	title: Reply to Rheumatologists' perspective on coronavirus disease 19: is heparin the dark horse for COVID-19? Heparin has multiple possible mechanisms of action which may support its use for COVID-19. SARS coronavirus strain HSR1 multiplication can be directly inhibited by heparin as evidenced by reduction of viral plaques by 50% on addition of heparin to Vero cell cultures [3] . One of the mechanisms of inhibition of cellular entry of SARS coronavirus is via lactoferrin binding [4] . SARS-CoV-2 entry into a cell via the ACE2 receptor leads to shedding of this receptor [6] . Furthermore, RAAS (renin-angiotensin-aldosterone system) activation is linked to thrombosis by multiple mechanisms [9] . Therefore, ACE2 downregulation by SARS-CoV-2 may lead to enhanced thrombosis. To summarize, SARS-CoV-2 can possibly activate the RAAS axis via ACE2 shedding and promote thrombosis. The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 receptor binding domain undergoes conformational change upon heparin binding.	./cache/cord-308499-xqmguqyi.txt	./txt/cord-308499-xqmguqyi.txt