id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307653-nyr6mtj1	Palmeira, Patricia	Why is SARS-CoV-2 infection milder among children?	2020-05-11		.txt	text/plain	3455	163	40	As with SARS-CoV, COVID-19 is believed to be initiated by the binding of the SARS-CoV-2 envelope-anchored spike protein to the outer surface of the angiotensin-converting enzyme 2 (ACE2) catalytic domain (13) , promoting endocytosis where viral and host membranes fuse and consequent entry of the virus into the host cell. (16) reported that ACE2 pulmonary expression is concentrated mainly in type II alveolar cells, which express many other genes that could favor viral replication, thus offering an explanation for the severe alveolar damage associated with SARS-CoV-2 infection. In agreement with the hypothesis that ACE2 expression levels have a significant role in acute respiratory distress syndrome (ARDS), which also occurs in COVID-19, an experimental mouse model of H5N1 virus-induced lung injury and death showed ACE2 downregulation following infection (25) .	./cache/cord-307653-nyr6mtj1.txt	./txt/cord-307653-nyr6mtj1.txt