id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306431-r83n27la	Chan, Chak-Ming	The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function	2009-05-04		.txt	text/plain	4794	276	55	title: The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function Consistent with the Vero E6 cells data (Fig. 2) , our in vivo results further validate the importance of cysteine-rich, Yxx and diacidic domains of 3a (Fig. 1A) in 3a's pro-apoptotic function. In this study, we generated mutant 3a constructs, 3a-CS, 3a-YA and 3a-DE (Fig. 1A) , and investigated the functional significance of the cysteine-rich, Yxx and diacidic domains on 3a's pro-apoptotic activity. We previously reported caspase-8 activation in 3a-WTexpressing Vero E6 cells , and our in vivo data also showed that cytochrome c can modulate 3a-WT-induced apoptosis . Over-expression of severe acute respiratory syndrome coronavirus 3b protein induces both apoptosis and necrosis in Vero E6 cells The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway	./cache/cord-306431-r83n27la.txt	./txt/cord-306431-r83n27la.txt