id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306365-7cydmgn2	Ami, Yasushi	Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice	2008-04-01		.txt	text/plain	5090	250	55	Our results show that both low-virulent Pp infection, and administration of LPS derived from Escherichia coli, induced elastase in the lungs and enhanced the replication of SARS-CoV, resulting in exacerbation of the respiratory disease caused by SARS-CoV infection and a high mortality rate. Thus, mice co-infected with Pp + Fr-mo developed severe respiratory disease, suggesting the possibility that elastase produced by Pp infection exacerbated infection by SARS-CoV adapted to mice. An important condition for sustaining high titers beyond four days p.i. would be that of high replication in the lungs in an early phase of infection, which could be facilitated by elastase induced by Pp. These data suggest that severe respiratory disease caused by co-infection of Pp and mouse-adapted SARS-CoV is attributable to the high replication of virus in the lungs, for which the elastase produced by Pp infection is probably responsible.	./cache/cord-306365-7cydmgn2.txt	./txt/cord-306365-7cydmgn2.txt