id author title date pages extension mime words sentences flesch summary cache txt cord-305093-og4k3fc7 Konno, Yoriyuki SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant 2020-09-04 .txt text/plain 3192 210 62 Phylogenetic analyses and functional assays reveal that SARS-CoV-2-related viruses from bats and pangolins also encode truncated ORF3b gene products with strong anti-interferon activity. Although 177 three additional ORF3b proteins of SARS-CoV-related viruses from bats (HKU3-2, 178 GX2013 and Yunnan2011) were shorter than 39 amino acids in length, they did not 179 exhibit anti-IFN-I activity, most likely because of their poor expression and/or 180 stability (Figures 2C and S2B) . mean values of three independent experiments with SEM are shown, 648 and statistically significant differences (P < 0.05) compared to the SeV-infected 649 empty vector-transfected cells (#) and the same amount of the SARS The mean values of three independent 753 experiments with SEM are shown, and statistically significant differences (P < 0.05) 754 compared to the SeV-infected empty vector-transfected cells (#) and the same 755 amount of the SARS-CoV-2 ORF3b WT ./cache/cord-305093-og4k3fc7.txt ./txt/cord-305093-og4k3fc7.txt