id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304355-y3fagw3t	Pan, Boyu	Chinese herbal compounds against SARS-CoV-2: puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor	2020-11-11		.txt	text/plain	4390	212	45	Here, we identified puerarin (PubChem CID: 5281807), quercetin (PubChem CID: 5280343) and kaempferol (PubChem CID: 5280863) as potential compounds with binding activity to ACE2 by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). In this study, we first screened out puerarin as the candidate compound targeting human ACE2 from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, and identified the potential effective herbs containing puerarin through TCMSP analysis platform. The possible interaction of these compounds with ACE2 was further investigated by molecular docking and surface plasmon resonance assays, and the results support the view that puerarin and quercetin could significantly impair the binding of viral S-protein to its human ACE2 receptor, shedding light on CHM-based new drug discovery against COVID-19 (See workflow scheme in Figure 1 ). To screen the potential CHM compounds targeting human ACE2 receptor, Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed.	./cache/cord-304355-y3fagw3t.txt	./txt/cord-304355-y3fagw3t.txt