id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304176-yloqrblw	Tunesi, S.	Prescribing COVID-19 treatments: what we should never forget	2020-05-13		.txt	text/plain	701	42	51	authors: Tunesi, S.; Bourgarit, A. COVID-19-induced proinflammatory status looks to trigger most severe SARS-CoV-2 forms (2). Many drugs have been hypothesized to be directly active against COVID-19 only because of a supposed antiviral activity: remdesivir, a molecule originally tested against Ebola virus, shows in vivo activity against MERS-CoV (5) but there is actually no real evidence of in vivo activity against COVID-19; lopinavir/ritonavir, a well-known protease inhibitor used in HIV treatment, has been widely used before randomized clinical trials showed his inefficacy in mortality reduction (6); chloroquine and hydroxychloroquine, which are largely used in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) treatment, show modest antiviral effects, but mortality due to QT elongation-related cardiac events is a matter of concern (7). Conversely, preliminary data about a potential role of ACE inhibitors in favouring the onset of severe forms of SARS-CoV-2 infection induced a massive change in antihypertensive drugs prescription that caused the onset of severe cardiovascular events (9).	./cache/cord-304176-yloqrblw.txt	./txt/cord-304176-yloqrblw.txt