id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304139-ya3d7u9b	Bosmann, Markus	Complement Activation during Critical Illness: Current Findings and an Outlook in the Era of COVID-19	2020-07-15		.txt	text/plain	2000	104	35	230-240) report on the association between alternative complement pathway activity and better survival in patients with critical illness (3). The alternative pathway hemolytic assay (AH50) and total complement activity (CH50) tests were retrospectively analyzed in a single-center heterogeneous cohort of n = 321 patients with acute respiratory distress syndrome (33%), with suspected sepsis (63%), and on mechanical ventilation (96%). Inappropriate complement activity may result in the unloading of harmful effector functions on host cells, with the consequence of disease-causing tissue injury and organ dysfunction during critical illness. Complement activation may occur early during SARS-CoV-2 infection by the direct interaction of viral proteins with the MBL (mannose-binding lectin) and ficolin pathway, rather than the alternative pathway. In another experimental study, the host transcriptional response in SARS-CoV-2-infected A549 human lung epithelial cells included the differential expression of C3, C1R, and other complement proteins (10) . Increased alternative complement pathway function and improved survival during critical illness	./cache/cord-304139-ya3d7u9b.txt	./txt/cord-304139-ya3d7u9b.txt