id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303056-bdse9o26	Okada, Masaji	Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models	2007-04-20		.txt	text/plain	1290	81	56	The production of neutralizing antibodies against SARS CoV was observed in the serum from mice immunized with S DNA vaccine SARS (M) DNA vaccine and N DNA vaccine induced murine T cell responses against SARS [4] . Human neutralizing antibodies were induced from SCID-PBL/hu mice vaccines with SARSS [6] and M DNA vaccines (Fig. 2) . Titer of neutralizing antibody in the serum from SCID-PBL/hu mice immunized with SARS (M) DNA vaccine was 1:10. SARS S DNA vaccine which elicits effective neutralizing antibody responses that generate protective immunity in a mouse model [9] . Furthermore, SARS M DNA as well as SARSS DNA vaccine induce human neutralizing antibodies against SARS CoV by the SCID-PBL/hu model. Therefore, the effect of combination immunization with such SARS vaccines (M vaccine and S vaccine) and the specificity of human monoclonal neutralizing antibodies are now being studied. A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice	./cache/cord-303056-bdse9o26.txt	./txt/cord-303056-bdse9o26.txt