id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302166-tah3jdw0	Zhang, Shen-Ying	Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?	2020-06-18		.txt	text/plain	1601	88	41	We suggest that these patients may become critically ill because of monogenic inborn errors that disrupt protective immunity to SARS-CoV-2. We suggest that these patients may become critically ill because of monogenic inborn errors that disrupt protective immunity to SARS-CoV-2. Studies since 1996 have identified a number of monogenic inborn errors of immunity (IEIs) underlying life-threatening infectious diseases, including specific viral diseases, in previously healthy patients 1,3-6 . The search for monogenic IEIs conferring predisposition to severe COVID-19 in previously healthy children and young or even middle-aged adults should therefore involve the genome-wide, agnostic testing of genetic hypotheses (see also COVID Human Genetic Effort) 10 . The discovery of monogenic IEIs to SARS-CoV-2 should help unravel the mechanistic basis of the immunopathogenesis of severe COVID-19 in young, previously healthy individuals. A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection	./cache/cord-302166-tah3jdw0.txt	./txt/cord-302166-tah3jdw0.txt