id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-301556-f3m9gwvo	Huang, Jessie	SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response	2020-09-18		.txt	text/plain	6737	319	49	Serially passaging these epithelial spheres generated >10 30 iAT2s per starting sorted tdTomato+ cell over 225 days in culture (Hurley et al., 2020) , generating cells that maintained expression of AT2 marker genes including surfactants as shown by single cell RNA sequencing (scRNA-Seq) ( Figure 1C -D, Figure S1 ) and providing a stable source of human primary-like AT2 cells for viral infection disease modeling. Compared to other published datasets of SARS-CoV-2 infection models in Calu-3, J o u r n a l P r e -p r o o f A549-ACE2, and primary (non-alveolar) normal human bronchial epithelium (NHBE) (Blanco-Melo et al., 2020) , iAT2s were able to uniquely capture the downregulation of AT2-specific programs, such as decreased surfactant gene expression and loss of lamellar body gene ontology (GO) terms (comparative gene set enrichment based on lung-related GO biological processes; Figure S3 ).	./cache/cord-301556-f3m9gwvo.txt	./txt/cord-301556-f3m9gwvo.txt